BDBM562814 US11407721, Example 61

SMILES Fc1ccc(C[C@H]2O[C@@H]([C@@H](N(C2=O)c2ccncc2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=VPGKHHKAWPXNLG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562814   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562814BDBM562814(US11407721, Example 61)
Affinity DataIC50: 1.58E+4nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent