BDBM562816 (2S,5R,6S)-5,6-Bis(4-chlorophenyl)-2-(2-fluoro-4-(methylsulfonyl)benzyl)-4-(pyridin-3-yl)morpholin-3-one and (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(2-fluoro-4-(methylsulfonyl)benzyl)-4-(pyridin-3-yl)morpholin-3-one::US11407721, Example 63

SMILES CS(=O)(=O)c1ccc(C[C@H]2O[C@@H](C(N(C2=O)c2cccnc2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(F)c1

InChI Key InChIKey=FPKXWYRDEQIPKH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562816   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562816BDBM562816(US11407721, Example 63 | (2S,5R,6S)-5,6-Bis(4-chlo...)
Affinity DataIC50: 2.00E+4nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
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Date in BDB:
10/28/2022
Entry Details
US Patent