BDBM562825 (5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)thiomorpholin-3-one::US11407721, Example 72

SMILES Clc1ccc(cc1)[C@H]1C(CC2CC2)C(=O)CS[C@H]1c1cccc(Cl)c1

InChI Key InChIKey=ZGKYOMGTRZWPLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 562825   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562825BDBM562825(US11407721, Example 72 | (5R,6S)-6-(3-Chlorophenyl...)
Affinity DataIC50: 1.25E+3nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562825BDBM562825(US11407721, Example 72 | (5R,6S)-6-(3-Chlorophenyl...)
Affinity DataIC50: 6.17E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent