BDBM562828 2-((2R,5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-isopropyl-1,1-dioxido-3-oxothiomorpholin-2-yl)acetic acid and 2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-isopropyl-1,1-dioxido-3-oxothiomorpholin-2-yl)acetic acid::US11407721, Example 75

SMILES CC(C)N1[C@@H]([C@H](c2cccc(Cl)c2)S(=O)(=O)[C@@H](CC(O)=O)C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=ISMHSIODMKAFIJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562828   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562828BDBM562828(US11407721, Example 75 | 2-((2R,5R,6S)-6-(3-Chloro...)
Affinity DataIC50: 2.41E+3nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
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Date in BDB:
10/28/2022
Entry Details
US Patent