BDBM562830 (3R,4S,8S)-4-(3-Chlorophenyl)-3-(4-chlorophenyl)-2-isopropyltetrahydropyrrolo[1,2-a]pyrazine-1,6(2H,7H)-dione::US11407721, Example 77

SMILES CC(C)N1[C@@H]([C@@H](N2[C@@H](CCC2=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key InChIKey=VFQSDHHWNIJHMY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562830   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562830BDBM562830(US11407721, Example 77 | (3R,4S,8S)-4-(3-Chlorophe...)
Affinity DataIC50: 3.18E+3nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
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Date in BDB:
10/28/2022
Entry Details
US Patent