BDBM565146 US11414404, Ex. # 23

SMILES Cc2c(Nc1c(F)ccc(NS(=O)(=O)CCCF)c1Cl)ccc3ncn(C)c(=O)c23

InChI Key InChIKey=VVLVISDSGRHLMB-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 565146   

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565146BDBM565146(US11414404, Ex. # 23)
Affinity DataIC50: 16nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565146BDBM565146(US11414404, Ex. # 23)
Affinity DataIC50: 52nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)