BDBM565685 US11414431, Compound I-253

SMILES CNc1cc(Nc2cccn([C@@H]3C[C@@H](C3)OC)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC

InChI Key InChIKey=JKRUNZGYOLBZSN-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565685   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565685(US11414431, Compound I-253 | US12221453, Compound ...)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM565685(US11414431, Compound I-253 | US12221453, Compound ...)
Affinity DataKd:  0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMVEscan® assay (D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM565685(US11414431, Compound I-253 | US12221453, Compound ...)
Affinity DataKd: <0.200nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent