BDBM567205 US11420968, Example A8b

SMILES [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)-c1ccc(cc1)N1CCC[C@@H]1c1ccccc1C1CC1

InChI Key InChIKey=XAAZYOXXBPRYRS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 567205   

TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM567205(US11420968, Example A8b)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM567205(US11420968, Example A8b)
Affinity DataIC50: 33nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-xl protein with its ligand in an assay based on fluorescence polarization methodolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM567205(US11420968, Example A8b)
Affinity DataIC50: 230nMAssay Description:Inhibition of Bcl-Xl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM567205(US11420968, Example A8b)
Affinity DataIC50: 4.10E+3nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-xl protein with its ligand in an assay based on fluorescence polarization methodolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent