BDBM567728 US11420968, Example F91b

SMILES CN1CCN(C2CC3(C2)CCN(CC3)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC[C@H]4CC[C@](C)(O)CC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)[C@H](C1)c1ccccc1C1CC1

InChI Key InChIKey=GHGYXKOMFUVEJU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 567728   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567728BDBM567728(US11420968, Example F91b)
Affinity DataIC50: 0.0630nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567728BDBM567728(US11420968, Example F91b)
Affinity DataIC50: 0.0630nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567728BDBM567728(US11420968, Example F91b)
Affinity DataIC50: 0.25nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2-G101 protein with its ligand in an assay based on time-resolved fluorescence re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567728BDBM567728(US11420968, Example F91b)
Affinity DataIC50: 27nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567728BDBM567728(US11420968, Example F91b)
Affinity DataIC50: 27nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent