BDBM567961 (R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)methyl)-6-(2-(difluoromethyl)-4-methoxyphenyl)pyridin-3-yl)piperidin-3-yl)-2,2-difluoroethan-1-ol and (S)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)methyl)-6-(2-(difluoromethyl)-4-methoxyphenyl)pyridin-3-yl)piperidin-3-yl)-2,2-difluoroethan-1-ol::US11420970, Example 162

SMILES COc1ccc(-c2cc(Cn3cnc4c(N)ncnc34)c(cn2)N2CCC[C@@](N)(C2)[C@H](O)C(F)F)c(c1)C(F)F

InChI Key InChIKey=GDDLHAQSCGAKGC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 567961   

TargetHistone-lysine N-methyltransferase NSD2(Human)
Novartis

US Patent
LigandPNGBDBM567961((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 5.5nMAssay Description:This assay employed LC-MS/MS technology to monitor the SAH production from the NSD2 enzymatic reaction. The enzymatic reaction was performed in white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent