BDBM572120 4-Dimethylamino-but-2-enoic acid {3-methoxy-4-[3-(quinazolin-2- ylamino)-pyrrolidine-1-carbonyl]- phenyl}-amide::US11447493, Example 85

SMILES COc1cc(NC(=O)\C=C\CN(C)C)ccc1C(=O)N1CC[C@H](C1)Nc1ncc2ccccc2n1

InChI Key InChIKey=SIGKFKBFXQQJJH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 572120   

LigandChemical structure of BindingDB Monomer ID 572120BDBM572120(4-Dimethylamino-but-2-enoic acid {3-methoxy-4-[3-(...)
Affinity DataIC50: 5.50E+3nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 572120BDBM572120(4-Dimethylamino-but-2-enoic acid {3-methoxy-4-[3-(...)
Affinity DataIC50: 5.50E+3nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 572120BDBM572120(4-Dimethylamino-but-2-enoic acid {3-methoxy-4-[3-(...)
Affinity DataIC50: 5.50E+3nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent