BDBM572241 3-[4-(1,8- diazaspiro[5.5]undecan- 8-yl)-1H-pyrrolo[2,3- b]pyridin-3- yl]isothiazole::US11447505, Example E121

SMILES C1CCC2(CCCN(C2)c2ccnc3[nH]cc(-c4ccsn4)c23)NC1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 572241   

TargetSerine/threonine-protein kinase MRCK beta(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572241(3-[4-(1,8- diazaspiro[5.5]undecan- 8-yl)-1H-pyrrol...)
Affinity DataKi:  0.0490nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetRho-associated protein kinase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572241(3-[4-(1,8- diazaspiro[5.5]undecan- 8-yl)-1H-pyrrol...)
Affinity DataKi:  386nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent