BDBM572263 4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- pyrrolo[2,3-b]pyridine-3-carbonitrile::US11447505, Example E187

SMILES N#Cc1c[nH]c2nccc(N3CCC[C@@]4(CCCCN4)C3)c12

InChI Key InChIKey=LMNVPKCUVZQIRI-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 572263   

TargetSerine/threonine-protein kinase MRCK beta(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572263(4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- pyrro...)
Affinity DataKi:  0.179nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase MRCK alpha(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572263(4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- pyrro...)
Affinity DataKi:  0.249nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572263(4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- pyrro...)
Affinity DataKi:  44.2nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572263(4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- pyrro...)
Affinity DataKi:  152nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent