BDBM573682 ((R)-3- (pyrrolidin-2- ylmethyl)-1H- indol-4-ol::US11453689, Compound I-3::US11453689, Compound I-50

SMILES Oc1cccc2[nH]cc(C[C@H]3CCCN3)c12

InChI Key InChIKey=PVFAYAZDVYXQFR-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 573682   

Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM573682(US11453689, Compound I-3 | US11453689, Compound I-...)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM573682(US11453689, Compound I-3 | US11453689, Compound I-...)
Affinity DataEC50: <1.00E+3nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM573682(US11453689, Compound I-3 | US11453689, Compound I-...)
Affinity DataEC50: <1.00E+3nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM573682(US11453689, Compound I-3 | US11453689, Compound I-...)
Affinity DataIC50: 2.75E+3nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent