BDBM573954 2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-amino-9H-purin-9-yl)-2,10-dioxido-2,10- disulfanylhexahydro-14H-15,12a- (epoxymethano)-5,8-methanofuro[3,2-l] [1,3,6,9,11,2,10]pentaoxadiphosphacyclotetra- decin-7(12H)-yl]-1,9-dihydro-6H-purin-6-one (Diastereomer 1)::US11453697, Example 139::US11453697, Example 140::US11453697, Example 141::US11453697, Example 142

SMILES Nc1nc2c(ncn2[C@@H]2O[C@@H]3COP(=O)(S)O[C@H]4[C@H]5OCC4(COP(=O)(S)O[C@@H]2C3)O[C@H]5n2cnc3c(N)ncnc32)c(=O)[nH]1

InChI Key InChIKey=AMBILNITMOGFQG-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 573954   

LigandChemical structure of BindingDB Monomer ID 573954BDBM573954(US11453697, Example 139 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 573954BDBM573954(US11453697, Example 139 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50: <1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573954BDBM573954(US11453697, Example 139 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 573954BDBM573954(US11453697, Example 139 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573954BDBM573954(US11453697, Example 139 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  6.20nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 573954BDBM573954(US11453697, Example 139 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  12.9nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 573954BDBM573954(US11453697, Example 139 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  175nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent