BDBM573954 2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-amino-9H-purin-9-yl)-2,10-dioxido-2,10- disulfanylhexahydro-14H-15,12a- (epoxymethano)-5,8-methanofuro[3,2-l] [1,3,6,9,11,2,10]pentaoxadiphosphacyclotetra- decin-7(12H)-yl]-1,9-dihydro-6H-purin-6-one (Diastereomer 1)::US11453697, Example 139::US11453697, Example 140::US11453697, Example 141::US11453697, Example 142

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H]2C[C@H]1OP(S)(=O)OCC13CO[C@@H]([C@@H](O1)n1cnc4c(N)ncnc14)[C@@H]3OP(S)(=O)OC2

InChI Key

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 573954   

LigandPNGBDBM573954(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573954(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50:  12.9nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573954(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573954(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50:  175nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573954(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50:  1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573954(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50: <1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573954(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50:  6.20nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent