BDBM574056 5-amino-3-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-amino-9H-purin-9-yl)-2,10-dihydroxy-2,10- disulfidohexahydro-14H-15,12a- (epoxymethano)-5,8-methanofuro[3,2- l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetra- decin-7(12H)-yl]-3,6-dihydro-7H- [1,2,3]triazolo[4,5-d]pyrimidin-7-one (Diastereomer 1)::US11453697, Example 184::US11453697, Example 185::US11453697, Example 186::US11453697, Example 187

SMILES Nc1nc2c(nnn2[C@@H]2O[C@@H]3COP(O)(=S)O[C@H]4[C@H]5OC[C@]4(COP(O)(=S)O[C@@H]2C3)O[C@H]5n2cnc3c(N)ncnc32)c(=O)[nH]1

InChI Key InChIKey=WMELFACDBNNVSE-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 574056   

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 574056BDBM574056(US11453697, Example 184 | 5-amino-3-[(5S,7R,8R,12a...)
Affinity DataEC50: <1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 574056BDBM574056(US11453697, Example 184 | 5-amino-3-[(5S,7R,8R,12a...)
Affinity DataEC50:  6.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 574056BDBM574056(US11453697, Example 184 | 5-amino-3-[(5S,7R,8R,12a...)
Affinity DataEC50:  30.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 574056BDBM574056(US11453697, Example 184 | 5-amino-3-[(5S,7R,8R,12a...)
Affinity DataEC50:  201nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent