BDBM577300 US11472811, Example 82B

SMILES Nc1nc2n(ncc2c2nc(nn12)-c1ccco1)[C@H](C(=O)NCC1(O)COC1)c1ccccc1

InChI Key InChIKey=WZFWTQIIRBONOA-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 577300   

TargetAdenosine receptor A2a(Human)
Beigene

US Patent
LigandPNGBDBM577300(US11472811, Example 82B)
Affinity DataKi:  1.70nMAssay Description:Binding affinity of test compounds to four human adenosine receptors, A1, A2A, A2B and A3 was determined in radioligand competitive binding assay (co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetAdenosine deaminase(Human)
Beigene

US Patent
LigandPNGBDBM577300(US11472811, Example 82B)
Affinity DataIC50: 3.80nMAssay Description:HEK293-A2AR-luc2p/CRE/Hygro cells were seeded at a density of 5,000 cells/well in DMEM with 1% FBS and 1 U/mL adenosine deaminase (ADA) (Sigma). Afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
Beigene

US Patent
LigandPNGBDBM577300(US11472811, Example 82B)
Affinity DataKi:  7.20nMAssay Description:Binding affinity of test compounds to four human adenosine receptors, A1, A2A, A2B and A3 was determined in radioligand competitive binding assay (co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent