BDBM577700 (−)-3-chloro-4-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-5-methyl-5,7,9a,10,10a,11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-13-carboxylic acid N-ethylethanamine salt (Enantiomer 2)::US11478451, Example 105
SMILES CCc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C
InChI Key InChIKey=NNIZSKXUZBQRNK-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 577700
TargetApoptosis regulator Bcl-2/Bcl2-associated agonist of cell death [103-127,M117N](Homo sapiens (Human))
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1 [1-212]/Bad BH3 Peptide(Homo sapiens (Human))
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: 1.60E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...More data for this Ligand-Target Pair