BDBM578572 3-[3-(2,4- dimethylthiazol- 5-yl)-5-fluoro-2- pyridyl]-3- methoxy-5,5- dimethyl-6-oxo- cyclohexene-1- carbonitrile (Enantiomer A)::US11479539, Compound 191::US11479539, Compound 195::US11479539, Compound 93

SMILES COC1(CC(C)(C)C(=O)C(=C1)C#N)c1ncc(F)cc1-c1sc(C)nc1C

InChI Key InChIKey=IPPNFZMDHWFJRL-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 578572   

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578572(US11479539, Compound 93 | 3-[3-(2,4- dimethylthiaz...)
Affinity DataEC50:  5nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578572(US11479539, Compound 93 | 3-[3-(2,4- dimethylthiaz...)
Affinity DataEC50:  12nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578572(US11479539, Compound 93 | 3-[3-(2,4- dimethylthiaz...)
Affinity DataEC50:  1.30E+3nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent