BDBM578792 4-(aminomethyl)-6-(2-(trifluoromethyl)pyrimidin-5- yl)phthalazin-1(2H)-one::US11479551, Example 3-12::US11492351, Example 3-12

SMILES NCc1n[nH]c(=O)c2ccc(cc12)-c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=JWJJIWGLELFOAH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 578792   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM578792(US11492351, Example 3-12 | 4-(aminomethyl)-6-(2-(t...)
Affinity DataIC50: 2.10E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM578792(US11492351, Example 3-12 | 4-(aminomethyl)-6-(2-(t...)
Affinity DataIC50: 2.10E+5nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM578792(US11492351, Example 3-12 | 4-(aminomethyl)-6-(2-(t...)
Affinity DataIC50: 1.00E+6nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM578792(US11492351, Example 3-12 | 4-(aminomethyl)-6-(2-(t...)
Affinity DataIC50: 1.00E+6nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent