BDBM579107 2-bromo-2-cyclopropyl acetamide::US11479552, Example 1

SMILES CO[C@@H]1CN(CC[C@@H]1[C@H]1C[C@@H]2CC[C@H](C1)N2[C@H](C1CC1)C(N)=O)c1ncc(F)cn1

InChI Key InChIKey=AXOUSJFGEOVDQT-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 579107   

TargetOrexin receptor type 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM579107(2-bromo-2-cyclopropyl acetamide | US11479552, Exam...)
Affinity DataEC50:  0.990nMAssay Description:HEK293 (human embryonic kidney 293) cells with forced expression of human OX1R (hOX1R) or human OX2R (hOX2R) were seeded in a 384-well microplate (Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM579107(2-bromo-2-cyclopropyl acetamide | US11479552, Exam...)
Affinity DataEC50:  2.30nMAssay Description:Human Embryonic Kidney cells 293 (HEK293) cells with forced expression of hOX1R or hOX2R were seeded in a 384-well microplate (Greiner) at 10,000 per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM579107(2-bromo-2-cyclopropyl acetamide | US11479552, Exam...)
Affinity DataEC50: >100nMAssay Description:HEK293 (human embryonic kidney 293) cells with forced expression of human OX1R (hOX1R) or human OX2R (hOX2R) were seeded in a 384-well microplate (Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM579107(2-bromo-2-cyclopropyl acetamide | US11479552, Exam...)
Affinity DataEC50:  4.70E+3nMAssay Description:Human Embryonic Kidney cells 293 (HEK293) cells with forced expression of hOX1R or hOX2R were seeded in a 384-well microplate (Greiner) at 10,000 per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent