BDBM579829 4-acetyl- N- [2- hydroxy- 3-(1,2,3,4- tetrahydro- isoquino- lin-2- yl)propyl] piperazine-::US11485731, Example 1B

SMILES CC(=O)N1CCN(CC1)C(=O)NCC(O)CN1CCc2ccccc2C1

InChI Key InChIKey=SSAICJGODGDTLW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 579829   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579829BDBM579829(US11485731, Example 1B | 4-acetyl- N- [2- hydroxy-...)
Affinity DataIC50: 9.91E+3nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent