BDBM579860 N-[2- hydroxy- 3-(1,2,3,4- tetrahydro- isoquinolin- 2- yl)propyl]- 2,3,4,5-::US11485731, Example 1K

SMILES OC(CNC(=O)N1CCCc2ccccc2C1)CN1CCc2ccccc2C1

InChI Key InChIKey=ZRHGKWZDINXRPG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 579860   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579860BDBM579860(US11485731, Example 1K | N-[2- hydroxy- 3-(1,2,3,4...)
Affinity DataIC50: 412nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent