BDBM579965 3-(3,4- dihydro- isoquinolin- 2(1H)-yl)- 2-hydroxy- propyl 3- (dimethyl- carbamoyl)::US11485731, Example 4S

SMILES CN(C)C(=O)C1CN(C1)C(=O)OCC(O)CN1CCc2ccccc2C1

InChI Key InChIKey=CKIWGEQCABIJHZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 579965   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579965BDBM579965(US11485731, Example 4S | 3-(3,4- dihydro- isoquino...)
Affinity DataIC50: 5.03E+3nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent