BDBM580864 1-(3-((3-(2-aminopyrimidin-5-yl)-5- morpholinophenyl)sulfonyl)azetidin-1-yl)-2- methylpropan-1-one::US11492348, Compound 76

SMILES CC(C)C(=O)N1CC(C1)S(=O)(=O)c1cc(cc(c1)-c1cnc(N)nc1)N1CCOCC1

InChI Key InChIKey=SMNRAFUKBPHRSF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 580864   

LigandPNGBDBM580864(US11492348, Compound 76 | 1-(3-((3-(2-aminopyrimid...)
Affinity DataIC50: 300nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580864(US11492348, Compound 76 | 1-(3-((3-(2-aminopyrimid...)
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent