BDBM581334 US11504381, Compound 17::US11548866, Compound 17

SMILES Nc1cc(Cl)cnc1N1CCN(CC1c1ccc(Cl)cc1)C(=O)CCCC(O)=O

InChI Key InChIKey=PMOMIYXCXVUGOK-UHFFFAOYSA-N

Data  2 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 581334   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581334(US11504381, Compound 17 | US11548866, Compound 17)
Affinity DataKd:  1.50E+4nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581334(US11504381, Compound 17 | US11548866, Compound 17)
Affinity DataKd:  1.50E+4nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581334(US11504381, Compound 17 | US11548866, Compound 17)
Affinity DataKi:  6.00E+4nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Ligature Therapeutics

US Patent
LigandPNGBDBM581334(US11504381, Compound 17 | US11548866, Compound 17)
Affinity DataKi:  6.00E+4nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent