BDBM581733 US11512080, Compound I-21

SMILES O=C1CCN(C(=O)N1)c1ccccn1

InChI Key InChIKey=CLTJSERAQIAUHR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 581733   

TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581733BDBM581733(US11512080, Compound I-21)
Affinity DataKd:  2.80E+4nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581733BDBM581733(US11512080, Compound I-21)
Affinity DataIC50: 4.00E+4nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581733BDBM581733(US11512080, Compound I-21)
Affinity DataIC50: 1.00E+5nMAssay Description:Equal volumes of His-tagged CRBN-DDB1 complex (56 nM) was mixed with Eu-cryptate labeled Anti-6HIS-monoclonal antibody (50× dilution from the commerc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent