BDBM582448 US11518764, Compound I-461::acsmedchemlett.2c00502 OICR 13098D, 56

SMILES COc1nc2n(CC(=O)Nc3cc(nc(F)c3Cl)N3CCN(C)C[C@@H]3C)cc(-c3cc(C(N)=O)c(O)c(F)c3F)c2c(=O)n1C

InChI Key InChIKey=YAULVJSIQRRWRW-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 582448   

TargetB-cell lymphoma 6 protein(Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandChemical structure of BindingDB Monomer ID 582448BDBM582448(US11518764, Compound I-461 | acsmedchemlett.2c0050...)
Affinity DataKd:  87.6nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandChemical structure of BindingDB Monomer ID 582448BDBM582448(US11518764, Compound I-461 | acsmedchemlett.2c0050...)
Affinity DataKd:  88nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandChemical structure of BindingDB Monomer ID 582448BDBM582448(US11518764, Compound I-461 | acsmedchemlett.2c0050...)
Affinity DataKd:  88nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed