BDBM585337 5-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine::US11530198, Example 115

SMILES Nc1ncc(N2CCN(CC2)c2ccc(cc2)C(F)(F)F)c(N)n1

InChI Key InChIKey=LYLVOYFHKFSZQJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 585337   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585337(US11530198, Example 115 | 5-(4-(4-(trifluoromethyl...)
Affinity DataIC50: 6.17nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585337(US11530198, Example 115 | 5-(4-(4-(trifluoromethyl...)
Affinity DataIC50: 813nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent