BDBM585844 US11530229, Compound 60

SMILES Cc1cc(nc(n1)C1CC1)C(=O)Nc1cccc(c1)C1(Cc2nncn2C)COC1

InChI Key InChIKey=VMVFABHXOIBCAE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 585844   

LigandPNGBDBM585844(US11530229, Compound 60)
Affinity DataIC50: 3.5nMAssay Description:The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585844(US11530229, Compound 60)
Affinity DataIC50: 5nMAssay Description:The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM585844(US11530229, Compound 60)
Affinity DataKd:  20nMAssay Description:Binding affinity to CBl-b (unknown origin) assessed as dissociation constant by Surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM585844(US11530229, Compound 60)
Affinity DataIC50: 20nMAssay Description:Inhibition of Cbl-b (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM585844(US11530229, Compound 60)
Affinity DataIC50: 21nMAssay Description:Inhibition of CBL-B (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM585844(US11530229, Compound 60)
Affinity DataIC50: 21nMAssay Description:Inhibition of Cbl-b (unknown origin) ubiquitination by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM585844(US11530229, Compound 60)
Affinity DataIC50: 790nMAssay Description:Inhibition of Cbl-b (unknown origin) by Cellular substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed