BDBM590941 N-(8-amino-7-cyanoisoquinolin-3- yl)cyclopropanecarboxamide::US11566003, Compound 8

SMILES Nc1c(ccc2cc(NC(=O)C3CC3)ncc12)C#N

InChI Key InChIKey=NPMLKKSXFARWLM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 590941   

LigandPNGBDBM590941(N-(8-amino-7-cyanoisoquinolin-3- yl)cyclopropaneca...)
Affinity DataKi:  19.6nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandPNGBDBM590941(N-(8-amino-7-cyanoisoquinolin-3- yl)cyclopropaneca...)
Affinity DataKi:  20nMAssay Description:Inhibition of HPK1 (1 to 346 residues) (unknown origin) assessed as inhibition constant by Lanthascreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed