BDBM592055 Synthesis of 2-acryloyl-N-((2S)-1-(((63S,4S,Z)-11-ethyl-12-(2-((S)-1-methoxyethyl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)amino)-3-methyl-1-oxobutan-2-yl)-N-methyl-5-oxa-2,9-diazaspiro[3.5]nonane-9-carboxamide::US11566007, Example A735

SMILES CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3nc(cs3)-c3ccc1c2c3)NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCOC11CN(C1)C(=O)C=C)-c1cccnc1[C@H](C)OC

InChI Key InChIKey=MEXMPINDCBWWDY-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 592055   

TargetGTPase KRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [G13C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas(Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas(Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61K](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [G13D](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [G12S](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61R](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent