BDBM592243 4-(((1r,4R)-4-(4-cyano-1H- pyrazol-1-yl)cyclohexyl)amino)- 6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-((R)-2-fluoro- 3-hydroxy-3- methylbutyl)nicotinamide::US11572362, Compound 24

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1N[C@H]1CC[C@@H](CC1)n1cc(cn1)C#N)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=LNTFTUGLEBNSKQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 592243   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM592243(4-(((1r,4R)-4-(4-cyano-1H- pyrazol-1-yl)cyclohexy...)
Affinity DataIC50: 1nMAssay Description:The enzyme and peptide solution were incubated with compound for 15 minutes at room temp before the reaction was initiated by the addition of ATP. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent