BDBM592253 6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-(((1r,4R)-4- (4-cyclopropyl-1H-1,2,3-triazol-1- yl)cyclohexyl)amino)-N-((R)-2- fluoro-3-hydroxy-3- methylbutyl)nicotinamide::US11572362, Compound 32

SMILES CC(C)(O)[C@H](F)CNC(=O)c3cnc(c1ccc2cc(C#N)cnn12)cc3N[C@@H]6CC[C@@H](n5cc(C4CC4)nn5)CC6

InChI Key InChIKey=GFUKGQWFOLYBJW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 592253   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM592253(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-(((1r,...)
Affinity DataIC50: 1nMAssay Description:The enzyme and peptide solution were incubated with compound for 15 minutes at room temp before the reaction was initiated by the addition of ATP. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent