BDBM592282 (R)-4-((4-(1,3,4-thiadiazol-2- yl)bicyclo[2.2.2]octan-1- yl)amino)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-fluoro-3- hydroxy-3- methylbutyl)nicotinamide::US11572362, Compound 61

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC12CCC(CC1)(CC2)c1nncs1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=VXFCZFCNOYSVTK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 592282   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM592282((R)-4-((4-(1,3,4-thiadiazol-2- yl)bicyclo[2.2.2]o...)
Affinity DataIC50: 1nMAssay Description:The enzyme and peptide solution were incubated with compound for 15 minutes at room temp before the reaction was initiated by the addition of ATP. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent