BDBM592293 6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-(((1r,4R)-4- (2-(difluoromethyl)-2H-tetrazol-5- yl)cyclohexyl)amino)-N-((R)-2- fluoro-3-hydroxy-3- methylbutyl)nicotinamide::US11572362, Compound 72

SMILES CC(C)(O)[C@H](F)CNC(=O)c3cnc(c1ccc2cc(C#N)cnn12)cc3N[C@@H]5CC[C@@H](C4=NC(C(F)F)N=N4)CC5

InChI Key InChIKey=HHUKDXVQBJDNGF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 592293   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM592293(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-(((1r,...)
Affinity DataIC50: 0.639nMAssay Description:The enzyme and peptide solution were incubated with compound for 15 minutes at room temp before the reaction was initiated by the addition of ATP. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent