BDBM595096 US11584714, Compound 1124

SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCN2C(=O)[C@@H](CCc2ccccc2)NCC(O)=O)cc1

InChI Key InChIKey=RDWKYFPETGYQMH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 595096   

TargetC-type lectin domain family 4 member K(Human)
Omeros

US Patent
LigandPNGBDBM595096(US11584714, Compound 1124 | US12195427, Compound 1...)
Affinity DataIC50: 50nMAssay Description:The MASP-2 assay utilizes a fluorogenic substrate, based on the cleavage site for its natural substrate C2. The assay was run at room temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM595096(US11584714, Compound 1124 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595096(US11584714, Compound 1124 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595096(US11584714, Compound 1124 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol was carried out as follows. Test compounds were serially diluted in DMSO and then 100 nL of each dilution was transferred t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM595096(US11584714, Compound 1124 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM595096(US11584714, Compound 1124 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595096(US11584714, Compound 1124 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay utilizes a fluorogenic substrate, based on the cleavage site for its natural substrate C2. The assay was run at room temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent