BDBM595566 (R)-1-(5-(((R)-2-(((1r,4R)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-2H-tetrazol-2-yl)ethyl ethyl carbonate (Compound 21) and (R)-1-(5-(((S)-2-(((1r,4S)-4-((5′-chloro-6-(((4-cyanotetrahydro-2H-pyran-4-yl)methyl)amino)-[2,4′-bipyridin]-2′-yl)amino)cyclohexyl)amino)propoxy)methyl)-2H-tetrazol-2-yl)ethyl ethyl carbonate ::US11591322, Compound 22

SMILES CCOC(=O)O[C@H](C)n1nnc(COC[C@H](C)N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2cccc(NCC3(CCOCC3)C#N)n2)n1

InChI Key InChIKey=HQVRFXBZJOXOKH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 595566   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Algen Biotechnologies

US Patent
LigandPNGBDBM595566(US11591322, Compound 22 | (R)-1-(5-(((R)-2-(((1r,4...)
Affinity DataIC50: 3.75nMAssay Description:To each well of a 96-well plate was added 5× kinase assay buffer with 10 mM DTT (6 μL), 500 μM ATP (1 μL), 5×CDK substrate (10 μL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent