BDBM595576 4-(((5′-chloro-2′-(((1R,4r)-4-(((R)-1-((1-methyl-1H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (Compound 36) and 4-(((5′-chloro-2′-(((1S,4r)-4-(((S)-1-((1-methyl-1H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile ::US11591322, Compound 37

SMILES C[C@@H](COCc1nnnn1C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1

InChI Key InChIKey=POFPVNICPWZABV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 595576   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Algen Biotechnologies

US Patent
LigandPNGBDBM595576(US11591322, Compound 37 | 4-(((5′-chloro-2&#...)
Affinity DataIC50: 2.5nMAssay Description:To each well of a 96-well plate was added 5× kinase assay buffer with 10 mM DTT (6 μL), 500 μM ATP (1 μL), 5×CDK substrate (10 μL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent