BDBM595760 US11591331, Example 90

SMILES CCc1cc2ncc(CN3CCN([C@@H]4C[C@H]34)c3ccc(nc3)C(=O)NC)cc2[nH]c1=O

InChI Key InChIKey=PVOOFJMJDHPMBT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 595760   

TargetPoly [ADP-ribose] polymerase 1(Human)
Acerand Therapeutics (Hong Kong)

US Patent
LigandPNGBDBM595760(US11591331, Example 90 | US20250221987, Example 1-...)
Affinity DataIC50: 0.700nMAssay Description:1) 50 ng/mL of histone coating buffer was prepared with 1×PBS, and 25 μL of coating buffer was transferred to a 384-well reaction plate, which was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Acerand Therapeutics (Hong Kong)

US Patent
LigandPNGBDBM595760(US11591331, Example 90 | US20250221987, Example 1-...)
Affinity DataIC50: 7.60nMAssay Description:Assays based on fluorescent polarization (FP) have been widely utilized in drug discovery due to the homogenous format, robust performance and lack o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Acerand Therapeutics (Hong Kong)

US Patent
LigandPNGBDBM595760(US11591331, Example 90 | US20250221987, Example 1-...)
Affinity DataIC50: 11.4nMAssay Description:1) 100 ng/mL of histone coating buffer was prepared with 1×PBS, and 25 μL of coating buffer was transferred to a 384-well reaction plate, which was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Acerand Therapeutics (Hong Kong)

US Patent
LigandPNGBDBM595760(US11591331, Example 90 | US20250221987, Example 1-...)
Affinity DataIC50: 6.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent