BDBM601317 (R)-N-((S)-2-(dimethylamino)-3-(4-hydroxy-2-(trifluoromethyl)phenyl)propyl)-3-(pyridin-3-yl)-3-(1-(trifluoromethyl)cyclopropyl) propanamide ::US11634396, Compound 255

SMILES CN(C)[C@H](CNC(=O)C[C@H](c1cccnc1)C1(CC1)C(F)(F)F)Cc1ccc(O)cc1C(F)(F)F

InChI Key InChIKey=MMRLQBCFNQRPAY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 601317   

TargetKappa-type opioid receptor(Human)
Epiodyne

US Patent
LigandPNGBDBM601317((R)-N-((S)-2-(dimethylamino)-3-(4-hydroxy-2-(trifl...)
Affinity DataIC50: 300nMAssay Description:KOR β-Arrestin Agonist and Antagonist assays were preformed using the Tango OPRK1-bla U2OS cells from Invitrogen and purchased from ThermoFisher...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Epiodyne

US Patent
LigandPNGBDBM601317((R)-N-((S)-2-(dimethylamino)-3-(4-hydroxy-2-(trifl...)
Affinity DataIC50: 3.00E+3nMAssay Description:CHO Tag-lite human mOR stable cell line from Cisbio (NCBI accession number: NM_000914.3, Bedford, Mass.) were seeded and grown to approximately 80% c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
Go to US Patent