BDBM601962 7'-((4-(S- methylsulfonimidoyl)phenyl)amino)- 1',2'-dihydro-3'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 79::US20240150369, Compound 79

SMILES CS(=N)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1

InChI Key InChIKey=WHDHBZVTAJDTDO-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 601962   

TargetCDK2/Cyclin-E2(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 16nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 16nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 16nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 89nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 89nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 89nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 1(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 146nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 1(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 146nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 146nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 172nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 172nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 172nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 291nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 291nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601962(US11643416, Compound 79 | 7'-((4-(S- methylsulfoni...)
Affinity DataIC50: 291nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent