BDBM601963 4-amino-N-(3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)benzenesulfonamide::US11643416, Compound 84::US20240150369, Compound 84

SMILES Nc1ccc(cc1)S(=O)(=O)Nc1ncc2cc3NNC(=O)C4(CCCCC4)n3c2n1

InChI Key InChIKey=QGIFQLWCNWTFNA-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 601963   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 207nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 207nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCDK2/Cyclin-E2(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 207nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 571nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 571nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 571nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 1(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 1(Human)
Pharmacosmos Holding

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601963(US11643416, Compound 84 | 4-amino-N-(3'-oxo-2',3'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2025
Entry Details
US Patent