BDBM60544 BDBM50448674::US9102669, 46::US9102669, 63

SMILES Cn1cc(cn1)-c1ccc(nn1)N1CCC(CC1)n1ccc2ccc(F)cc12

InChI Key InChIKey=YJKHGJGDWHXZBG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 60544   

TargetAcyl-CoA desaturase 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60544(US9102669, 63 | BDBM50448674 | US9102669, 46)
Affinity DataIC50: 11nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60544(US9102669, 63 | BDBM50448674 | US9102669, 46)
Affinity DataIC50: 23nMAssay Description:Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using stearoyl-[9,10-3H]-CoA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60544(US9102669, 63 | BDBM50448674 | US9102669, 46)
Affinity DataIC50: 23nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent

TargetStearoyl-CoA desaturase(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM60544(US9102669, 63 | BDBM50448674 | US9102669, 46)
Affinity DataIC50: 25nMAssay Description:Inhibition of SCD1 in human A431 cells assessed as [13C]-palmitic acid conversion to [13C]-palmitoleic acid after 4 hrs by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60544(US9102669, 63 | BDBM50448674 | US9102669, 46)
Affinity DataIC50: 165nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2016
Entry Details
US Patent