BDBM608375 (Z)-15-chloro-4-(cyclopropylsulfonyl)-96- fluoro-13,61-dimethyl-26,27-dihydro- 11H,24H,61H-10-oxa-8-thia-4-aza-2(3,2)- pyrazolo[5,1-c][1,4]oxazina-1(4,1)-indola- 6(3,5)-pyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid::US11691989, Compound 31

SMILES Cc1c(C(O)=O)n2CCCOc3cc(SCc4cc(CN(Cc5nn6CCOCc6c5-c5c(Cl)ccc2c15)S(=O)(=O)C1CC1)nn4C)cc1cc(F)ccc31

InChI Key InChIKey=GRXXZBQBEPHMLM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608375   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-323](Homo sapiens (Human))
Ascentage Pharma (Suzhou)

US Patent
LigandPNGBDBM608375((Z)-15-chloro-4-(cyclopropylsulfonyl)-96- fluoro-1...)
Affinity DataIC50:  16nMAssay Description:The relative binding potency of representative Compounds of the Disclosure was determined by a fluorescence polarization (FP) assay. The method used ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent