BDBM608806 US11701371, Compound 76::US11707471, Compound 76::US20230277570, Compound 76

SMILES COc1cccc2c(ncnc12)N1CCC(CCP(O)(O)=O)CC1

InChI Key InChIKey=IXXUGBPAQOKGTM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 608806   

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataKi: <2nMAssay Description:Inhibition of ENPP1 (unknown origin) using cGAMP as substrate assessed as inhibition constant at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataKi: <2nMAssay Description:Binding affinity to human ENPP1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataKi:  4nMAssay Description:Inhibition of ENPP1 in mouse plasma using [32P]cGAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataIC50: 6.20nMAssay Description:Experimental Method:1. Preparation of 1× reaction solution: 50 mM Tris-HCl (pH 7.5), 10 mM NaCl, 0.5 mM CaCl2, 1 μM ZnCl2, 0.01% Tween-20, 0.01% BSA....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataIC50: 500nMAssay Description:Selected compounds of Table 1, Table 2 and other derivatives were prepared and assessed in an ENPP1 activity assay using thymidine monophosphate para...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataIC50: 500nMAssay Description:Selected compounds of Table 1, Table 2 and other derivatives were prepared and assessed in an ENPP1 activity assay using thymidine monophosphate para...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataIC50: 500nMAssay Description:Radiolabeled 32P cGAMP was synthesized by incubating unlabeled ATP (1 mM) and GTP (1 mM) doped with 32P-ATP with 2 μM purified recombinant porci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataIC50: 500nMAssay Description:ENPP1 activity assay using thymidine monophosphate paranitrophenol (TMP-pNP) as a substrate. Enzyme reactions were prepared with TMP-pNP (2 μM),...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataIC50: 500nMAssay Description:Selected compounds of Table 1, Table 2 and other derivatives were prepared and assessed in an ENPP1 activity assay using thymidine monophosphate para...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataIC50: 500nMAssay Description:Selected compounds of Table 1, Table 2 and other derivatives were prepared and assessed in an ENPP1 activity assay using thymidine monophosphate para...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent