BDBM610450 2-Phenyl-N-(pyridin-3-yl)imidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 1

SMILES O=C(Nc1cccnc1)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=UVTJZQHSPPYGDG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 610450   

TargetGlycogen synthase kinase-3 alpha(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 5.30nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 17nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 17.1nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 660nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 660nMAssay Description:Inhibition of Tau (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed