BDBM612326 BDBM612424::BDBM612425::N'-(8-(difluoromethoxy)-1,2,3,5,6,7- hexahydro-s-indacen-4- ylcarbamoyl)-2-(2-hydroxypropan-2- yl)thiazole-5-sulfonimidamide::US11724992, Example 27

SMILES CC(C)(O)c1ncc(s1)S(N)(=O)=NC(=O)Nc1c2CCCc2c(OC(F)F)c2CCCc12

InChI Key InChIKey=AZPNGVAOWCFSOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 612326   

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM612326(BDBM612424 | BDBM612425 | N'-(8-(difluoromethoxy)-...)
Affinity DataIC50:  600nMAssay Description:THP-1 cells were purchased from the American Type Culture Collection and sub-cultured according to instructions from the supplier. Prior to experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM612326(BDBM612424 | BDBM612425 | N'-(8-(difluoromethoxy)-...)
Affinity DataIC50:  120nMAssay Description:THP-1 cells were purchased from the American Type Culture Collection and sub-cultured according to instructions from the supplier. Prior to experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM612326(BDBM612424 | BDBM612425 | N'-(8-(difluoromethoxy)-...)
Affinity DataIC50:  3.00E+3nMAssay Description:THP-1 cells were purchased from the American Type Culture Collection and sub-cultured according to instructions from the supplier. Prior to experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent