BDBM612377 BDBM612516::BDBM612517::N'-(1,2,3,5,6,7-hexahydro-s- indacen-4-ylcarbamoyl)-4-(2- hydroxypropan-2-yl)thiophene-2- sulfonimidamide

SMILES CC(C)(O)c1csc(c1)S(N)(=O)=NC(=O)Nc1c2CCCc2cc2CCCc12

InChI Key InChIKey=JCQRNNNBOOKAPS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 612377   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
IFM Therapeutics GmbH

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 612377BDBM612377(N'-(1,2,3,5,6,7-hexahydro-s- indacen-4-ylcarbamoyl...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity against NLRP3 in PMA-primed human THP-1 cells assessed as inhibition of gramicidin-induced IL-1beta release measured after 1 hr i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed