BDBM612843 BDBM613184::US11725010, Example 2
SMILES O=C(NCc1ccc2cc(CNCC3CCC3)[nH]c2c1)c1cc(=O)n2ccccc2n1
InChI Key InChIKey=MFQFZLWCFZZHAI-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 612843
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-SAM from METTL3/METTL14 (unknown origin) using 5'biotinylated-UACACUCGAUCUGGACUAAAGGUGCUC-3' RNA as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system using synthet...More data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 134nMAssay Description:Inhibition of METTL3/METTL14-mediated m6A mRNA expression in human SK-OV-3 cells incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 138nMAssay Description:Inhibition of METTL3/METTL14-mediated m6A mRNA expression in human Kasumi 1 cells incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 169nMAssay Description:Inhibition of METTL3/METTL14-mediated m6A mRNA expression in human Calu-6 cells incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:Inhibition of METTL3/METTL14-mediated m6A mRNA expression in human MV4-11 cells incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 264nMAssay Description:Inhibition of METTL3/METTL14-mediated m6A mRNA expression in human A549 cells incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Epics Therapeutics SA
Curated by ChEMBL
Epics Therapeutics SA
Curated by ChEMBL
Affinity DataIC50: 331nMAssay Description:Inhibition of METTL3/METTL14-mediated m6A mRNA expression in human FaDu cells incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair